iSEDs micro-flow cell captures the critical kinetics of red blood cells in a highly controlled testing environment. Utilizing a very small sample100 microlitersthe iSED captures the impact of the most critical phase of the early phase in the phenomenon of RBC sedimentationthe so-called rouleaux formationto produce erthrocyte sedimentation rate (ESR) results that are unaffected by the variables commonly associated with traditional ESR testing, such as mixing of the sample and temperature.